A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer

Abstract

CD47 is a signaling receptor for thrombospondin-1 and the counter-receptor for signal-regulatory protein-α (SIRPα). By inducing inhibitory SIRPα signaling, elevated CD47 expression by some cancers prevents macrophage phagocytosis. The anti-human CD47 antibody B6H12 inhibits tumor growth in several xenograft models, presumably by preventing SIRPα engagement… (More)
DOI: 10.18632/oncotarget.7100

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