A fully human monoclonal antibody to Staphylococcus aureus iron regulated surface determinant B (IsdB) with functional activity in vitro and in vivo.

@article{Ebert2010AFH,
  title={A fully human monoclonal antibody to Staphylococcus aureus iron regulated surface determinant B (IsdB) with functional activity in vitro and in vivo.},
  author={Tim Ebert and Sharon Smith and Greg Pancari and Desmond J. Clark and Richard Owen Hampton and Susan Secore and Victoria Towne and Hongxia Fan and Xin-min Wang and Xiaoqing Wu and Robin E Ernst and Barrett R Harvey and Adam C. Finnefrock and Fubao Wang and Charles Tan and Eberhard Durr and Leslie Cope and Annaliesa S Anderson and Zhiqiang An and Tessie McNeely},
  journal={Human antibodies},
  year={2010},
  volume={19 4},
  pages={
          113-28
        }
}
  • Tim Ebert, Sharon Smith, +17 authors Tessie McNeely
  • Published in Human antibodies 2010
  • Biology, Medicine
  • A fully human monoclonal antibody (CS-D7, IgG1) specific for the iron regulated surface determinant B (IsdB) of Staphylococcus aureus was isolated from the Cambridge Antibody Technology (CAT) scFv antibody library. As compared to previously described IsdB specific murine monoclonals, CS-D7 has a unique, non-overlapping binding site on IsdB, and exhibits increased in vivo activity. The antibody recognizes a conformational epitope spanning amino acids 50 to 285 and has a binding affinity of 340… CONTINUE READING

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    Human mAbs to Staphylococcus aureus IsdA Provide Protection Through Both Heme-Blocking and Fc-Mediated Mechanisms

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    Investigational drugs to treat methicillin-resistant Staphylococcus aureus.

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