A full rat-scale model of the basal ganglia and thalamocortical network to reproduce Parkinsonian tremor

@inproceedings{Morn2015AFR,
  title={A full rat-scale model of the basal ganglia and thalamocortical network to reproduce Parkinsonian tremor},
  author={Jan Mor{\'e}n and Jun Igarashi and Junichiro Yoshimoto and Kenji Doya},
  booktitle={BMC Neuroscience},
  year={2015}
}
We aim to investigate the precise mechanisms underlying Parkinsonian symptoms by large-scale simulation of realistic neural network models including the basal ganglia (BG), thalamus, the motor cortex and spinal cord. Parkinson ‘s disease is a midor late-age degenerative disorder of the central nervous system. The symptoms include akinesia, resting tremor, rigidity and gait problems. A principal cause of PD is the loss of dopaminergic neurons in the substantia nigra pars compacta. How the loss… CONTINUE READING
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A spiking neuron model of the basal ganglia circuitry that can generate behavioral variability

  • O Shouno, J Takeuchi, H Tsujino
  • The Basal Ganglia IX
  • 2009
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