A full‐UV spectrum absorbing daily use cream protects human skin against biological changes occurring in photoaging

@article{Seit2000AFS,
  title={A full‐UV spectrum absorbing daily use cream protects human skin against biological changes occurring in photoaging},
  author={Sophie Seit{\'e} and Alain C. Colige and Pascale Piquemal‐Vivenot and Christiane Montastier and Anny Fourtanier and C H Lapi{\`e}re and Betty V. Nusgens},
  journal={Photodermatology},
  year={2000},
  volume={16}
}
Background: There is overwhelming evidence that exposure of human skin to ultraviolet radiations (UVR) leads to the development of cutaneous photoaging and eventually to neoplasia. This study was designed to evaluate in humans the protection afforded by a daily use cream containing a photostable combination of UVB and UVA absorbers (Uvinul® N539, Parsol® 1789 and Mexoryl® SX) providing a continuous absorption through the entire UV spectrum, against damages induced by repeated daily exposure to… 
Sunscreens containing the broad‐spectrum UVA absorber, Mexoryl® SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results
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UVA exposure of human skin mainly produces reactive oxygen species (ROS) leading to DNA, cell and tissue damage, and to provide adequate protection, sunscreens or skin care products for daily use protective products need UVA absorbers combined with UVB ones.
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Two organic UV filters, terephthlylidene dicamphor sulphonic acid and drometrizole trisiloxane (Mexoryl XL, L'Oréal), provide effective protection from UV irradiation and offer improved safety profiles in terms of protection from UVA radiation.
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Clinical studies demonstrate that broad-spectrum protection in moisturizers or daily-care products can prevent the "silent" sub-erythemal cumulative effects of UVR from inadvertent sun exposure.
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Evidence suggests that visible light and infrared light may play a role in photoaging and should be considered when choosing a sunscreen, and further explores the requirements for an ideal sunscreen.
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TLDR
Broad-spectrum sunscreens are particularly useful to inhibit epidermal gene modifications like mutations on p53 gene, generation of thymine dimers, and induction of apoptosis or to minimize enzymatic damage to the dermal matrix.
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  • 2012
TLDR
The data demonstrate in vitro and in vivo that only well-balanced UVA-UVB sunscreens, absorbing over the entire UV spectrum are able to prevent or significantly reduce the associated biological damage.
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  • D. Maslin
  • Medicine
    International journal of dermatology
  • 2014
TLDR
The role of ultraviolet radiation in causing skin cancer is looked at; the available evidence on both the beneficial and harmful effects of sunscreen use is summarized; and practical advice on how to advise patients to best protect themselves from photocarcinogenesis is concluded.
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TLDR
This review focused on the technological and scientific aspects of photoprotection using sunglasses and clothing while attempting to dispel some of the misconceptions about sunscreens.
[Sunscreens. Protection against skin cancers and photoaging].
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[Sunprotection: possibilities and limitations].
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  • 2005
TLDR
Future perspectives in the development of sunscreens include DNA repair enzymes or factors, which can induce the endogenous cellular DNA repair system, and the risk to develop UV-induced skin malignancies is markedly reduced.
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