A fucoidan from Nemacystus decipiens disrupts angiogenesis through targeting bone morphogenetic protein 4.

@article{Wang2016AFF,
  title={A fucoidan from Nemacystus decipiens disrupts angiogenesis through targeting bone morphogenetic protein 4.},
  author={Wucheng Wang and Huanjun Chen and Lei Zhang and Yi Qin and Qifei Cong and Peipei Wang and K. K. Ding},
  journal={Carbohydrate polymers},
  year={2016},
  volume={144},
  pages={305-14}
}
A sulfated and acetylated fucoidan, named NDH01, was extracted from seaweed Nemacystus decipiens. NDH01 was composed of mannose, glucuronic acid, fucose, sulfate group and acetyl group in the molar ratio of 3.0: 14.4: 82.6: 34.3: 13.9. The backbone of NDH01 was fucose-free core, composed of α-d-1,2-Manp and β-d-1,4-GlcpA disaccharide repeat unit. The branches were attached at the C3, C4 and C6 of α-d-1,2-Manp. The sidechain was composed of α-l-1,3,4-Fucp, α-l-1,4-Fucp, α-l-1,3-Fucp and α-l-1,4… CONTINUE READING