A fresh start for stalled forks

Abstract

Replication forks often run into obstacles, such as DNA damage or cross-links, that block their progress. Thangavel et al. (1) and Zellweger et al. (2) identify enzymes that enable cells to cope with these obstacles and resume replication. When replication forks encounter a roadblock, they often perform a maneuver called fork reversal (3). The newly… (More)

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