A fresh look at tumor immunosurveillance and immunotherapy

  title={A fresh look at tumor immunosurveillance and immunotherapy},
  author={M. Smyth and D. Godfrey and J. Trapani},
  journal={Nature Immunology},
  • M. Smyth, D. Godfrey, J. Trapani
  • Published 2001
  • Medicine, Biology
  • Nature Immunology
  • Despite major advances in our understanding of adaptive immunity and dendritic cells, consistent and durable responses to cancer vaccines remain elusive and active immunotherapy is still not an established treatment modality. The key to developing an effective anti-tumor response is understanding why, initially, the immune system is unable to detect transformed cells and is subsequently tolerant of tumor growth and metastasis. Ineffective antigen presentation limits the adaptive immune response… CONTINUE READING
    Principles of tumor immunosurveillance and implications for immunotherapy


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