A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression

@article{Oh2009AFF,
  title={A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression},
  author={D. Y. Oh and Konstantin Baumann and Osamah Hamouda and Jana K Eckert and Konrad Neumann and Claudia K{\"u}cherer and Barbara Gunsenheimer Bartmeyer and Gabriele Poggensee and Nari Oh and Axel Pruss and Heiko K. Jessen and Ralf R. Schumann},
  journal={AIDS},
  year={2009},
  volume={23},
  pages={297–307}
}
Objectives:Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. TLR7 recognizes RNA of various viruses including HIV. The objective of this study was to examine the influence of individual genetic variations of TLR7 on the susceptibility to and progression of HIV disease. Method:We genotyped a population of 734 HIV-positive adults and 545 healthy controls for three TLR7 single nucleotide polymorphisms. The frequency of TLR7 genetic variations was… 
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