A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression.

@article{Oh2009AFF,
  title={A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression.},
  author={Djin-Ye Oh and Konstantin Baumann and Osamah Hamouda and Jana K Eckert and Konrad Neumann and Claudia Kuecherer and Barbara Bartmeyer and Gabriele Poggensee and Nari Oh and Axel Pruss and Heiko K. Jessen and R. Randall Schumann},
  journal={AIDS},
  year={2009},
  volume={23 3},
  pages={297-307}
}
OBJECTIVES Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. TLR7 recognizes RNA of various viruses including HIV. The objective of this study was to examine the influence of individual genetic variations of TLR7 on the susceptibility to and progression of HIV disease. METHOD We genotyped a population of 734 HIV-positive adults and 545 healthy controls for three TLR7 single nucleotide polymorphisms. The frequency of TLR7 genetic variations was… CONTINUE READING
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MyD88-dependent immune activation mediated by HIV-1encoded TLR ligands

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