A free radical theory of male infertility.

  title={A free radical theory of male infertility.},
  author={Robert John Aitken},
  journal={Reproduction, fertility, and development},
  volume={6 1},
  pages={19-23; discussion 23-4}
There is a growing body of evidence to indicate that a significant factor in the aetiology of male infertility involves a loss of sperm function as a consequence of oxidative stress. This stress originates from the excessive generation of reactive oxygen species by the spermatozoa and results in the peroxidation of unsaturated fatty acids in the sperm plasma membrane. It is possible that reactive oxygen species originating from infiltrating leucocytes could also stress the spermatozoa although… CONTINUE READING


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