A framework to understand the variations of PSD-95 expression in brain aging and in Alzheimer's disease

@article{Savioz2014AFT,
  title={A framework to understand the variations of PSD-95 expression in brain aging and in Alzheimer's disease},
  author={Armand Savioz and Genevi{\`e}ve Leuba and Philippe G Vallet},
  journal={Ageing Research Reviews},
  year={2014},
  volume={18},
  pages={86-94}
}
The postsynaptic density protein PSD-95 is a major element of synapses. PSD-95 is involved in aging, Alzheimer's disease (AD) and numerous psychiatric disorders. However, contradictory data about PSD-95 expression in aging and AD have been reported. Indeed in AD versus control brains PSD-95 varies according to regions, increasing in the frontal cortex, at least in a primary stage, and decreasing in the temporal cortex. In contrast, in transgenic mouse models of aging and AD PSD-95 expression is… CONTINUE READING
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