A framework to sub-type HLA supertypes.

  title={A framework to sub-type HLA supertypes.},
  author={Pandjassarame Kangueane and Meena Kishore Sakharkar and Ganapathy Rajaseger and Subhashini Bolisetty and Balasubramanian Sivasekari and Bing Zhao and Manickam Ravichandran and Paul Shapshak and Subramanian Subbiah},
  journal={Frontiers in bioscience : a journal and virtual library},
The human leukocyte antigen (HLA) alleles are extremely polymorphic among ethnic population and the peptide binding specificity varies for different alleles in a combinatorial manner. However, it has been suggested that majority of alleles can be covered within few HLA supertypes, where different members of a supertype bind similar peptides, yet exhibiting distinct repertoires. Since the overlap between different members of a supertype appears to be extensive, it is crucial to develop a… CONTINUE READING


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