A framework for assessing immunological correlates of protection in vaccine trials.

@article{Qin2007AFF,
  title={A framework for assessing immunological correlates of protection in vaccine trials.},
  author={Li Qin and Peter B. Gilbert and Lawrence Corey and M Juliana McElrath and Steven G. Self},
  journal={The Journal of infectious diseases},
  year={2007},
  volume={196 9},
  pages={1304-12}
}
A central goal of vaccine research is to identify a vaccine-induced immune response that predicts protection from infection or disease. The term "correlate of protection" has been used to refer to at least 3 distinct concepts, which has resulted in confusion surrounding this topic. We propose precise definitions of these different concepts of immune correlates, using the nomenclature "correlate of risk," "level 1 surrogate of protection," and "level 2 surrogate of protection." We suggest a… CONTINUE READING

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