A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

@article{Ogura2001AFM,
  title={A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease},
  author={Yasunori Ogura and Denise K. Bonen and Naohiro Inohara and Dan L. Nicolae and Felicia F. Chen and Richard Ramos and Heidi M. Britton and Thomas M. Moran and Reda Karaliuskas and Richard H. Duerr and Jean-Paul Achkar and Steven R. Brant and Theodore M. Bayless and Barbara S. Kirschner and Stephen Hanauer and Gabriel N{\'u}{\~n}ez and Judy H. Cho},
  journal={Nature},
  year={2001},
  volume={411},
  pages={603-606}
}
Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract, which is thought to result from the effect of environmental factors in a genetically predisposed host. A gene location in the pericentromeric region of chromosome 16, IBD1, that contributes to susceptibility to Crohn's disease has been established through multiple linkage studies, but the specific gene(s) has not been identified. NOD2, a gene that encodes a protein with homology to plant disease resistance gene… 
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