A fragment of the envelope protein from dengue-1 virus, fused in two different sites of the meningococcal P64k protein carrier, induces a functional immune response in mice.

@article{Hermida2004AFO,
  title={A fragment of the envelope protein from dengue-1 virus, fused in two different sites of the meningococcal P64k protein carrier, induces a functional immune response in mice.},
  author={Lisset Hermida and Rayner Rodr{\'i}guez and Laura Lazo and L{\'i}dice Bernardo and Ricardo Alexandre da Silva and A{\'i}da Zulueta and Carlos L{\'o}pez and Jorge Martin and Iris Vald{\'e}s and Delfina del Rosario and Gerardo Guill{\'e}n and Mar{\'i}a Guadalupe Guzm{\'a}n},
  journal={Biotechnology and applied biochemistry},
  year={2004},
  volume={39 Pt 1},
  pages={107-14}
}
Previously we have reported the capacity of the fusion protein PD3, composed of the P64k protein and the envelope (E) fragment from amino acids (aa) 286-426 of dengue-2 virus (DEN-2), to induce a functional immune response in mice against the homologous virus. In that case, the E fragment was inserted within the lipoyl-binding domain of the meningococcal P64k protein. In the present study, to test the functionality of the same E region from dengue-1 (DEN-1), a similar construct was made… CONTINUE READING

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