A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo.

@article{Porkka2002AFO,
  title={A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo.},
  author={Kimmo V.K. Porkka and Pirjo M Laakkonen and Jason A. Hoffman and Michele Bernasconi and Erkki Ruoslahti},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 11},
  pages={7444-9}
}
We used a screening procedure to identify protein domains from phage-displayed cDNA libraries that bind both to bone marrow endothelial progenitor cells and tumor vasculature. Screening phage for binding of progenitor cell-enriched bone marrow cells in vitro, and for homing to HL-60 human leukemia cell xenograft tumors in vivo, yielded a cDNA fragment that encodes an N-terminal fragment of human high mobility group protein 2 (HMGN2, formerly HMG-17). Upon i.v. injection, phage displaying this… CONTINUE READING

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We used a screening procedure to identify protein domains from phage - displayed cDNA libraries that bind both to bone marrow endothelial progenitor cells and tumor vasculature .
We used a screening procedure to identify protein domains from phage - displayed cDNA libraries that bind both to bone marrow endothelial progenitor cells and tumor vasculature .
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