A fragment of human TrpRS as a potent antagonist of ocular angiogenesis.

@article{Otani2002AFO,
  title={A fragment of human TrpRS as a potent antagonist of ocular angiogenesis.},
  author={Atsushi Otani and Bonnie M. Slike and Michael Ian Dorrell and J. H. Hood and Karen Kinder and Karla Lynn Ewalt and David Alan Cheresh and Paul R. Schimmel and Martin Friedlander},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 1},
  pages={
          178-83
        }
}
Pathological angiogenesis contributes directly to profound loss of vision associated with many diseases of the eye. Recent work suggests that human tyrosyl- and tryptophanyl-tRNA synthetases (TrpRS) link protein synthesis to signal transduction pathways including angiogenesis. In this study, we show that a recombinant form of a COOH-terminal fragment of TrpRS is a potent antagonist of vascular endothelial growth factor-induced angiogenesis in a mouse model and of naturally occurring retinal… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 49 CITATIONS

References

Publications referenced by this paper.

www.pnas.org cgi doi

  • J. Kao, J. Ryan, +8 authors C Y.
  • J. Biol. Chem
  • 1992

Similar Papers

Loading similar papers…