A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization.

@article{Olsson2004AFO,
  title={A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization.},
  author={A K Olsson and Helena Larsson and Johan Dixelius and Irja Johansson and Chunsik Lee and Cornelia Oellig and Ingemar Bj{\"o}rk and Lena Claesson-Welsh},
  journal={Cancer research},
  year={2004},
  volume={64 2},
  pages={599-605}
}
In this study, we show that recombinant human histidine-rich glycoprotein (HRGP) has potent antiangiogenic properties as judged from effects on a syngeneic tumor model in C57/bl6 mice. Growth of fibrosarcoma, a very aggressive tumor, was reduced by >60% by HRGP treatment, and tumor angiogenesis was dramatically decreased. Treatment with HRGP led to increased apoptosis and reduced proliferation in the tumors. In contrast, HRGP did not affect apoptosis or DNA synthesis in endothelial cells or… CONTINUE READING