A four-state Markov model of sleep-wakefulness dynamics along light/dark cycle in mice

Abstract

Behavioral states alternate between wakefulness (wk), rapid eye movement (rem) and non-rem (nrem) sleep at time scale of hours i.e., light and dark cycle rhythms and from several tens of minutes to seconds (i.e., brief awakenings during sleep). Using statistical analysis of bout duration, Markov chains of sleep-wk dynamics and quantitative EEG analysis, we… (More)
DOI: 10.1371/journal.pone.0189931

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