A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction.

@article{Steward2007AFO,
  title={A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction.},
  author={Oswald Steward and Fen Huang and John F. Guzowski},
  journal={Learning & memory},
  year={2007},
  volume={14 6},
  pages={433-45}
}
Stimulation paradigms that induce perforant path long-term potentiation (LTP) initiate phosphorylation of ERK1/2 and induce expression of a variety of immediate early genes (IEGs). These events are thought to be critical components of the mechanism for establishing the changes in synaptic efficacy that endure for hours or longer. Here we show that in mice, perforant path LTP can be induced using a standard protocol (repeated trains at 250 Hz), without accompanying increases in immunostaining… CONTINUE READING

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