A forkhead gene related to HNF-3beta is required for gastrulation and axis formation in the ascidian embryo.

@article{Olsen1997AFG,
  title={A forkhead gene related to HNF-3beta is required for gastrulation and axis formation in the ascidian embryo.},
  author={Catherine L. Olsen and William R Jeffery},
  journal={Development},
  year={1997},
  volume={124 18},
  pages={
          3609-19
        }
}
We have isolated a member of the HNF-3/forkhead gene family in ascidians as a means to determine the role of winged-helix genes in chordate development. The MocuFH1 gene, isolated from a Molgula oculata cDNA library, exhibits a forkhead DNA-binding domain most similar to zebrafish axial and rodent HNF-3beta. MocuFH1 is a single copy gene but there is at least one other related forkhead gene in the M. oculata genome. The MocuFH1 gene is expressed in the presumptive endoderm, mesenchyme and… CONTINUE READING

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