A forkhead-domain gene is mutated in a severe speech and language disorder

@article{Lai2001AFG,
  title={A forkhead-domain gene is mutated in a severe speech and language disorder},
  author={Cecilia S. L. Lai and Simon E. Fisher and Jane A. Hurst and Faraneh Vargha-Khadem and Anthony P. Monaco},
  journal={Nature},
  year={2001},
  volume={413},
  pages={519-523}
}
Individuals affected with developmental disorders of speech and language have substantial difficulty acquiring expressive and/or receptive language in the absence of any profound sensory or neurological impairment and despite adequate intelligence and opportunity. [] Key Result Here we show that the gene FOXP2, which encodes a putative transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain, is directly disrupted by the translocation breakpoint in CS.
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