A forkhead-domain gene is mutated in a severe speech and language disorder

@article{Lai2001AFG,
  title={A forkhead-domain gene is mutated in a severe speech and language disorder},
  author={C. Lai and S. Fisher and J. Hurst and F. Vargha-Khadem and A. Monaco},
  journal={Nature},
  year={2001},
  volume={413},
  pages={519-523}
}
  • C. Lai, S. Fisher, +2 authors A. Monaco
  • Published 2001
  • Biology, Medicine
  • Nature
  • Individuals affected with developmental disorders of speech and language have substantial difficulty acquiring expressive and/or receptive language in the absence of any profound sensory or neurological impairment and despite adequate intelligence and opportunity. [...] Key Result Here we show that the gene FOXP2, which encodes a putative transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain, is directly disrupted by the translocation breakpoint in CS.Expand Abstract
    1,687 Citations
    Functional genetic analysis of mutations implicated in a human speech and language disorder.
    • 159
    • PDF
    Deciphering the genetic basis of speech and language disorders.
    • 159
    • PDF
    Genetics of speech and language disorders.
    • 44
    • PDF
    A functional genetic link between distinct developmental language disorders.
    • 616
    • PDF
    The speech gene FOXP2 is not imprinted
    • 11
    Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits.
    • 363
    • PDF
    FOXP2 is not a major susceptibility gene for autism or specific language impairment.
    • 222
    Monogenic and chromosomal causes of isolated speech and language impairment
    • 12
    • PDF

    References

    SHOWING 1-10 OF 36 REFERENCES
    Localisation of a gene implicated in a severe speech and language disorder
    • 519
    • PDF
    Neural basis of an inherited speech and language disorder.
    • 378
    • PDF
    Praxic and nonverbal cognitive deficits in a large family with a genetically transmitted speech and language disorder.
    • 452
    • PDF
    Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly.
    • 306
    cDNAs with long CAG trinucleotide repeats from human brain
    • 109