A folded and functional synthetic PA1b: an interlocked entomotoxic miniprotein.

@article{Silva2009AFA,
  title={A folded and functional synthetic PA1b: an interlocked entomotoxic miniprotein.},
  author={Pedro Hugo Vieira da Silva and Anna Strzępa and Laurence Jouvensal and Isabelle Rahioui and Fr{\'e}d{\'e}ric Gressent and Agn{\`e}s F. Delmas},
  journal={Biopolymers},
  year={2009},
  volume={92 5},
  pages={436-44}
}
PA1b (Pea Albumin 1, subunit b) is a hydrophobic, 37-amino acid miniprotein isolated from pea seeds (Pivum sativum), crosslinked by three interlocked disulfide bridges, signature of the ICK (inhibitory cystine-knot) family. It acts as an entomotoxic factor against major insect pests in stored crops and vegetables, making it a promising bioinsecticide. Here we report an efficient and simple protocol for the production of large quantities of highly pure, biologically active synthetic PA1b. The… CONTINUE READING

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