A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide.

Abstract

A small molecule, protein mimetic based approach is shown to specifically inhibit lipid catalysed self-assembly of islet amyloid polypeptide (IAPP). The lipid-bound oligomerization of this peptide is implicated in cellular dysfunction of insulin secreting β-cells in type II diabetes. 
DOI: 10.1039/c3cc41452c

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