A focus on heme oxygenase-1 (HO-1) inhibitors.

@article{Pittal2013AFO,
  title={A focus on heme oxygenase-1 (HO-1) inhibitors.},
  author={V. Pittal{\`a} and L. Salerno and G. Romeo and M. Modica and M. Siracusa},
  journal={Current medicinal chemistry},
  year={2013},
  volume={20 30},
  pages={
          3711-32
        }
}
The aim of this review is to highlight the advances in the field of heme oxygenase-1 (HO-1) inhibitors over the past years, particularly from a medicinal chemistry point of view; progresses made in the field strongly helped to clarify physiological roles of the heme oxygenase (HO) system. HO is a family of ubiquitously expressed enzymes which regulate the regiospecific catabolism of heme leading to the formation of equimolar amounts of carbon monoxide (CO), ferrous iron (Fe⁺⁺), and biliverdin… Expand
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