A fluorescence in situ hybridization screen for E26 transformation-specific aberrations: identification of DDX5-ETV4 fusion protein in prostate cancer.

@article{Han2008AFI,
  title={A fluorescence in situ hybridization screen for E26 transformation-specific aberrations: identification of DDX5-ETV4 fusion protein in prostate cancer.},
  author={Bo Han and Rohit Mehra and Saravana M. Dhanasekaran and Jindan Yu and A Haritha Menon and Robert J. Lonigro and Xiaosong Wang and Yusong Gong and Lei Wang and Sunita Shankar and Bharathi Laxman and Rajal B Shah and Sooryanarayana Varambally and Nallasivam Palanisamy and Scott Arthur Tomlins and Chandan Kumar-Sinha and Arul M. Chinnaiyan},
  journal={Cancer research},
  year={2008},
  volume={68 18},
  pages={7629-37}
}
Recurrent gene fusions involving E26 transformation-specific (ETS) transcription factors ERG, ETV1, ETV4, or ETV5 have been identified in 40% to 70% of prostate cancers. Here, we used a comprehensive fluorescence in situ hybridization (FISH) split probe strategy interrogating all 27 ETS family members and their five known 5' fusion partners in a cohort of 110 clinically localized prostate cancer patients. Gene rearrangements were only identified in ETS genes that were previously implicated in… CONTINUE READING

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Chromosomal aberrations in prostate cancer.

Frontiers in bioscience : a journal and virtual library • 2007

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