• Corpus ID: 244462959

A fluid-structure instability driven physiomarker for aneurysm growth

@inproceedings{Zhao2021AFI,
  title={A fluid-structure instability driven physiomarker for aneurysm growth},
  author={Tom Y Zhao and Guy Elisha and Ethan M. I. Johnson and Sourav Halder and Ben C Smith and Bradley D. Allen and Michael Markl and Neelesh A. Patankar},
  year={2021}
}
Background: What is the physical mechanism that drives aneurysm formation and growth? The question remains fundamentally unresolved. Currently, the clinical diagnosis and treatment of an aneurysm are informed by correlative guidelines on its size and growth rate, along with a holistic consideration of possible symptoms and associated pathologies such as Marfan Syndrome, bicuspid aortic valve, etc. However, aneurysms can exhibit significant growth or rupture before size or rate criteria are met… 

Figures and Tables from this paper

References

SHOWING 1-10 OF 45 REFERENCES

The Relationship Between Aortic Root Size and Hypertension: An Unsolved Conundrum.

Increasing evidence seems to support the notion that aortic root dilatation, even in absence of aneurysmatic alterations, may be regarded as an hypertensive organ damage paralleling other preclinical markers whose unfavourable prognostic significance is firmly established.

Age-related vascular stiffening: causes and consequences

The underlying causes of age-related vessel stiffening are discussed, focusing on age- related crosslinking of the ECM proteins as well as through increased matrix deposition, and very recent work that demonstrates endothelial cells are mechano-sensitive to arterial stiffening, where changes in stiffness can directly impact EC health is discussed.

Thoracic Aortic Compliance as a Determinant of Rupture of Abdominal Aortic Aneurysms

  • L. Russo
  • Medicine, Engineering
    Annals of the New York Academy of Sciences
  • 2006
A striking increase in aortic compliance was observed in patients with ruptured AAAs, a relevant component of cardiac afterload, which is also determined by the relative amount of media proteins in large arteries as well as by pathological arterial processes.

The natural history of thoracic aortic aneurysms.

The relationship between aortic wall distensibility and rupture of infrarenal abdominal aortic aneurysm.

The measurement of AAA distensibility, diastolic BP, and diameter may provide a more accurate assessment of rupture risk than diameter alone and women have a shorter time to AAA rupture.