A floxed allele of the androgen receptor gene causes hyperandrogenization in male mice.

@article{Maclean2008AFA,
  title={A floxed allele of the androgen receptor gene causes hyperandrogenization in male mice.},
  author={Helen E. Maclean and W S Maria Chiu and Cathy A. Malchiodi Ma and Julie F McManus and Rachel A. Davey and Rhoda Cameron and Amanda J. Notini and Jeffrey Zajac},
  journal={Physiological genomics},
  year={2008},
  volume={33 1},
  pages={
          133-7
        }
}
We previously generated a conditional floxed mouse line to study androgen action, in which exon 3 of the androgen receptor (AR) gene is flanked by loxP sites, with the neomycin resistance gene present in intron 3. Deletion of exon 3 in global AR knockout mice causes androgen insensitivity syndrome, characterized by genotypic males lacking normal masculinization. We now report that male mice carrying the floxed allele (AR(lox)) have the reverse phenotype, termed hyperandrogenization. AR(lox… CONTINUE READING

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