A flow cytometric method for measuring neutralization of HIV-1 subtype B and E primary isolates.

Abstract

BACKGROUND Clinical trials testing candidate human immunodeficiency virus type 1 (HIV-1) vaccines have required the use of HIV neutralization assays to detect responses to specific geographic subtypes of HIV-1. The variability in results seen with current p24 neutralization assay endpoints prompted us to assess the utility of flow cytometry for monitoring… (More)

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