A flood of opioids, a rising tide of deaths.

@article{Okie2010AFO,
  title={A flood of opioids, a rising tide of deaths.},
  author={Susan Okie},
  journal={The New England journal of medicine},
  year={2010},
  volume={363 21},
  pages={
          1981-5
        }
}
  • S. Okie
  • Published 17 November 2010
  • Medicine
  • The New England journal of medicine
Faced with an epidemic of drug abuse and overdose deaths, the FDA has proposed a Risk Evaluation and Mitigation Strategy for prescription opioid pain relievers, involving improved education for physicians and patients about risks associated with long-acting opioids. 

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References

SHOWING 1-5 OF 5 REFERENCES

Patterns of abuse among unintentional pharmaceutical overdose fatalities.

TLDR
The majority of overdose deaths in West Virginia in 2006 were associated with nonmedical use and diversion of pharmaceuticals, primarily opioid analgesics.

Opioid Prescriptions for Chronic Pain and Overdose

TLDR
Patients receiving higher doses of prescribed opioids are at increased risk for overdose, which underscores the need for close supervision of these patients.

Emergency department visits involving nonmedical use of selected prescription drugs - United States, 2004-2008.

TLDR
Findings indicate substantial, increasing morbidity associated with the nonmedical use of prescription drugs in the United States during 2004-2008, despite recent efforts to control the problem.

Substance abuse treatment admissions involving abuse of pain relievers : 1998 and 2008