A flexible unified approach to the analysis of pre-clinical combination studies.

@article{Harbron2010AFU,
  title={A flexible unified approach to the analysis of pre-clinical combination studies.},
  author={Chris Harbron},
  journal={Statistics in medicine},
  year={2010},
  volume={29 16},
  pages={1746-56}
}
Combinations of drugs are increasingly being used in a variety of diseases. Pre-clinical experiments allow the responses of many drug compounds to be studied in combination with the goal of identifying compounds acting synergistically. This paper presents a unified approach to analysing data from combination studies, calculating a hierarchy of interaction indices to powerfully and flexibly describe the synergistic profile of the combination space studied, utilizing standard statistical software… CONTINUE READING

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