A flexible unified approach to the analysis of pre-clinical combination studies.

  title={A flexible unified approach to the analysis of pre-clinical combination studies.},
  author={Chris Harbron},
  journal={Statistics in medicine},
  volume={29 16},
Combinations of drugs are increasingly being used in a variety of diseases. Pre-clinical experiments allow the responses of many drug compounds to be studied in combination with the goal of identifying compounds acting synergistically. This paper presents a unified approach to analysing data from combination studies, calculating a hierarchy of interaction indices to powerfully and flexibly describe the synergistic profile of the combination space studied, utilizing standard statistical software… CONTINUE READING

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Distinction between multiple ligand exclusivity and competitiveness in receptor binding topology

  • TC Chou, JH Chou
  • The FASEB Journal
  • 1988
Highly Influential
4 Excerpts

The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curve

  • AV Hill
  • Journal of Physiology
  • 1910
Highly Influential
1 Excerpt

Statistical analysis of interactive cytotoxicity in human epidermal keratinocytes following exposure to a mixture of four metals

  • C Gennings, WH Carter, JA Campain, D-S Bae, RSH. Yang
  • Journal of Agricultural,
  • 2002
2 Excerpts

A statistical test for detecting and characterizing departures from additivity in drug/chemical combinations

  • KS Dawson, WH Carter, C. Gennings
  • Journal of Agricultural,
  • 2000
1 Excerpt

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