A flexible approach for understanding protein stability.

  title={A flexible approach for understanding protein stability.},
  author={Dennis R. Livesay and Sargis Dallakyan and Gregory G. Wood and Donald J. Jacobs},
  journal={FEBS letters},
  volume={576 3},
A distance constraint model (DCM) is presented that identifies flexible regions within protein structure consistent with specified thermodynamic condition. The DCM is based on a rigorous free energy decomposition scheme representing structure as fluctuating constraint topologies. Entropy non-additivity is problematic for naive decompositions, limiting the success of heat capacity predictions. The DCM resolves non-additivity by summing over independent entropic components determined by an… CONTINUE READING

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