A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer.

@article{Ma2008AFM,
  title={A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer.},
  author={Xiao-Jun Ma and Ranelle C. Salunga and Sonika Dahiya and Wilson Yong Hong Wang and Erin Carney and Virginie Durbecq and Adrian H Harris and Paul E Goss and Christos Sotiriou and Mark G. Erlander and Dennis C. Sgroi},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 9},
  pages={
          2601-8
        }
}
PURPOSE Histologic tumor grade is a well-established prognostic factor for breast cancer, and tumor grade-associated genes are the common denominator of many prognostic gene signatures. The objectives of this study are as follows: (a) to develop a simple gene expression index for tumor grade (molecular grade index or MGI), and (b) to determine whether MGI and our previously described HOXB13:IL17BR index together provide improved prognostic information. EXPERIMENTAL DESIGN From our previously… CONTINUE READING

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