A fish is not a mouse: understanding differences in background genetics is critical for reproducibility

  title={A fish is not a mouse: understanding differences in background genetics is critical for reproducibility},
  author={Marcus J Crim and Christian Lawrence},
  journal={Lab Animal},
Poorly controlled background genetics in animal models contributes to the lack of reproducibility that is increasingly recognized in biomedical research. The laboratory zebrafish, Danio rerio , has been an important model organism for decades in many research areas, yet inbred strains and traditionally managed outbred stocks are not available for this species. Sometimes incorrectly referred to as ‘inbred strains’ or ‘strains’, zebrafish wild-type lines possess background genetics that are often… Expand
2 Citations
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