A first step towards a mouse model for hepatitis C virus infection containing a human immune system.

@article{Robinet2011AFS,
  title={A first step towards a mouse model for hepatitis C virus infection containing a human immune system.},
  author={Eric Robinet and Thomas F Baumert},
  journal={Journal of hepatology},
  year={2011},
  volume={55 3},
  pages={718-720}
}
BACKGROUND & AIMS Studies of hepatitis C virus (HCV) infection, immunopathogenesis, and resulting liver diseases have been hampered by the lack of a small animal model. We developed humanized mice with human immune system and liver tissues to improve the studies of hepatitis C pathogenesis and treatment. METHODS To promote engraftment of human hepatocytes, we expressed a fusion protein of the FK506 binding protein (FKBP) and caspase 8 under the control of the albumin promoter (AFC8), which… CONTINUE READING