A first-passage-time theory for search and capture of chromosomes by microtubules in mitosis.

@article{Gopalakrishnan2011AFT,
  title={A first-passage-time theory for search and capture of chromosomes by microtubules in mitosis.},
  author={Manoj Gopalakrishnan and Bindu S. Govindan},
  journal={Bulletin of mathematical biology},
  year={2011},
  volume={73 10},
  pages={2483-506}
}
The mitotic spindle is an important intermediate structure in eukaryotic cell division, in which each of a pair of duplicated chromosomes is attached through microtubules to centrosomal bodies located close to the two poles of the dividing cell. Several mechanisms are at work toward the formation of the spindle, one of which is the 'capture' of chromosome pairs, held together by kinetochores, by randomly searching microtubules. Although the entire cell cycle can be up to 24 hours long, the… CONTINUE READING

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