A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer.

@article{Laxman2008AFM,
  title={A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer.},
  author={Bharathi Laxman and David Stuart Morris and Jianjun Yu and Javed Ather Siddiqui and Jie Cao and Rohit Mehra and Robert J. Lonigro and A. Tsodikov and John T. Wei and Scott Arthur Tomlins and Arul M. Chinnaiyan},
  journal={Cancer research},
  year={2008},
  volume={68 3},
  pages={645-9}
}
Although prostate-specific antigen (PSA) serum level is currently the standard of care for prostate cancer screening in the United States, it lacks ideal specificity and additional biomarkers are needed to supplement or potentially replace serum PSA testing. Emerging evidence suggests that monitoring the noncoding RNA transcript PCA3 in urine may be useful in detecting prostate cancer in patients with elevated PSA levels. Here, we show that a multiplex panel of urine transcripts outperforms… CONTINUE READING
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