A finely tuned regulatory circuit of the nicotinic acid degradation pathway in Pseudomonas putida.

@article{Jimenez2011AFT,
  title={A finely tuned regulatory circuit of the nicotinic acid degradation pathway in Pseudomonas putida.},
  author={J. I. Jimenez and Javier Ju{\'a}rez and J{\'e}ssica Leite Garcia and Eduardo A D{\'i}az},
  journal={Environmental microbiology},
  year={2011},
  volume={13 7},
  pages={
          1718-32
        }
}
The biochemistry of nicotinic acid (NA) degradation is known but the transcriptional control of the genes involved is still poorly studied. We report here the transcriptional regulatory circuit of the nic genes responsible for the aerobic degradation of NA in Pseudomonas putida KT2440. The three NA-inducible catabolic operons, i.e. nicAB, encoding the upper pathway that converts NA into 6-hydroxynicotinic acid (6HNA), and the nicCDEFTP and nicXR operons, responsible for channelling 6HNA to the… CONTINUE READING