A fifteen-month double-blind cross-over study of the efficacy and antigenicity of human and pork insulins.

@article{Home1984AFD,
  title={A fifteen-month double-blind cross-over study of the efficacy and antigenicity of human and pork insulins.},
  author={Philip D Home and Nicholas P. Mann and Alan S Hutchison and Rae-joon Park and Segayle Cereta Walford and M. Murphy and William G. Reeves},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={1984},
  volume={1 2},
  pages={
          93-8
        }
}
The antigenicity and efficacy of semi-synthetic human and pancreatic pork insulins have been compared in a double-blind double cross-over study in 96 insulin-treated diabetic patients. Transfer from pork to human insulin was associated with a 1.2 +/- 0.5 mmol/l deterioration (p less than 0.05) in the fasting blood glucose level, while the opposite change caused a 1.1 +/- 0.5 mmol/l improvement (p less than 0.05). After 4 months treatment, glycosylated haemoglobin levels were lower on pork (11.1… CONTINUE READING