A field isolate of Sendai virus: its high virulence to mice and genetic divergence from prototype strains

@article{Sakaguchi2005AFI,
  title={A field isolate of Sendai virus: its high virulence to mice and genetic divergence from prototype strains},
  author={Takemasa Sakaguchi and Katsuhiro Kiyotani and Miyoko Sakaki and Yutaka Fujii and T. Yoshida},
  journal={Archives of Virology},
  year={2005},
  volume={135},
  pages={159-164}
}
SummaryA field isolate of Sendai virus, the Hamamatsu strain, was far more virulent in mice than the prototype Z strain. The Hamamatsu strain replicated more efficiently in the mouse lung than the Z strain, causing deteriorating lung lesions. Nucleotide sequence analysis of the HN, F and M genes revealed that the Hamamatsu strain was divergent from the prototype Z, Harris and Fushimi strains. 
Identification of Mutations Associated with Attenuation of Virulence of a Field Sendai Virus Isolate by Egg Passage
TLDR
To determine the molecular basis for the attenuation of SeV pathogenicity by egg passage, entire genomes of representative SeV clones isolated during egg passages were sequenced and the significance of the mutations detected in the leader as well as in the L and HN genes was discussed.
Masking of the contribution of V protein to Sendai virus pathogenesis in an infection model with a highly virulent field isolate.
TLDR
The V protein seems to be potentially functional in the highly virulent Hamamatsu strain and to be prominent if virus replication is restricted, although it appears that the V protein is nonsense in a field isolate of Sendai virus.
Sendai virus, the mouse parainfluenza type 1: a longstanding pathogen that remains up-to-date.
TLDR
A review of Sendai virus, the murine parainfluenza virus type 1, aimed at drawing an exhaustive picture of this multifaceted pathogen.
Sendai Virus and Pneumonia Virus of Mice (PVM)
TLDR
Sendai virus infection of mice is investigated in some detail because it is a naturally occurring respirovirus of mice and therefore an excellent paradigm for a viral genus that causes significant morbidity in many mammalian species, including humans.
Passage of a Sendai Virus Recombinant in Embryonated Chicken Eggs Leads to Markedly Rapid Accumulation of U-to-C Transitions in a Limited Region of the Viral Genome
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The results suggest that a lack of C proteins could lead unexpectedly to strong selective pressures, and that the C proteins might play more critical roles in SeV replication than ever reported.
Contribution of the leader sequence to homologous viral interference among Sendai virus strains.
TLDR
Results indicate that homologous interference is partly dependent on the promoter sequence and suggest involvement of promoter activity for genome amplification related to host factors in viral interference, and suggest suppression of closely related human paramyxoviruses.
Conserved and Non-Conserved Regions in the Sendai Virus Genome: Evolution of a Gene Possessing Overlapping Reading Frames
TLDR
The entire genome of a virulent field isolate of Sendai virus, the Hamamatsu strain, is sequenced, and regions where changes were permissive and non-permissive, and the experimentally determined functional region were found to be conserved, showing that important regions for function were conserved during evolution.
A new paramyxovirus, Tianjin strain, isolated from common cotton-eared marmoset: genome characterization and structural protein sequence analysis
TLDR
Pairwise comparisons of amino acid identities and phylogenetic analysis with homologous sequences of known SeVs demonstrated that Tianjin strain represented a new evolutionary lineage of SeV.
Prevalence of specific neutralizing antibodies against Sendai virus in populations from different geographic areas: Implications for AIDS vaccine development using Sendai virus vectors
TLDR
To quantify SeV neutralizing antibodies (NAb) in human serum, a sensitive virus neutralization assay was developed using a SeV vector encoding green fluorescent protein and a significant correlation was observed between hPIV-1 ELISA and SeV NAb titers.
Illumination of Parainfluenza Virus Infection and Transmission in Living Animals Reveals a Tissue-Specific Dichotomy
TLDR
A dichotomy between PIV infection in the URT and trachea versus the lungs is revealed and a new model for studies of pathogenesis, development of live virus vaccines, and testing of antiviral therapies is defined.
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