A field isolate of Sendai virus: its high virulence to mice and genetic divergence from prototype strains

@article{Sakaguchi2005AFI,
  title={A field isolate of Sendai virus: its high virulence to mice and genetic divergence from prototype strains},
  author={Takemasa Sakaguchi and Katsuhiro Kiyotani and Miyoko Sakaki and Yutaka Fujii and T. Yoshida},
  journal={Archives of Virology},
  year={2005},
  volume={135},
  pages={159-164}
}
SummaryA field isolate of Sendai virus, the Hamamatsu strain, was far more virulent in mice than the prototype Z strain. The Hamamatsu strain replicated more efficiently in the mouse lung than the Z strain, causing deteriorating lung lesions. Nucleotide sequence analysis of the HN, F and M genes revealed that the Hamamatsu strain was divergent from the prototype Z, Harris and Fushimi strains. 
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The entire genome of a virulent field isolate of Sendai virus, the Hamamatsu strain, is sequenced, and regions where changes were permissive and non-permissive, and the experimentally determined functional region were found to be conserved, showing that important regions for function were conserved during evolution.
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Prevalence of specific neutralizing antibodies against Sendai virus in populations from different geographic areas: Implications for AIDS vaccine development using Sendai virus vectors
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To quantify SeV neutralizing antibodies (NAb) in human serum, a sensitive virus neutralization assay was developed using a SeV vector encoding green fluorescent protein and a significant correlation was observed between hPIV-1 ELISA and SeV NAb titers.
Illumination of Parainfluenza Virus Infection and Transmission in Living Animals Reveals a Tissue-Specific Dichotomy
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A dichotomy between PIV infection in the URT and trachea versus the lungs is revealed and a new model for studies of pathogenesis, development of live virus vaccines, and testing of antiviral therapies is defined.
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