A fibronectin mimetic motif improves integrin mediated cell biding to recombinant spider silk matrices.

@article{Widhe2016AFM,
  title={A fibronectin mimetic motif improves integrin mediated cell biding to recombinant spider silk matrices.},
  author={Mona Widhe and Nancy Dekki Shalaly and My Hedhammar},
  journal={Biomaterials},
  year={2016},
  volume={74},
  pages={256-66}
}
The cell binding motif RGD is the most widely used peptide to improve cell binding properties of various biomaterials, including recombinant spider silk. In this paper we use genetic engineering to further enhance the cell supportive capacity of spider silk by presenting the RGD motif as a turn loop, similar to the one found in fibronectin (FN), but in the silk stabilized by cysteines, and therefore denoted FNCC. Human primary cells cultured on FNCC-silk showed increased attachment, spreading… CONTINUE READING
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