A fibroblast-derived tumor cytotoxic factor/F-TCF (hepatocyte growth factor/HGF) has multiple functions in vitro.

@article{Shima1991AFT,
  title={A fibroblast-derived tumor cytotoxic factor/F-TCF (hepatocyte growth factor/HGF) has multiple functions in vitro.},
  author={Nobuyuki Shima and Yasuharu Itagaki and Masaya Nagao and Hideyo Yasuda and Takatoshi Morinaga and Kanji Higashio},
  journal={Cell biology international reports},
  year={1991},
  volume={15 5},
  pages={397-408}
}
We previously demonstrated that a tumor cytotoxic factor(F-TCF) purified from the culture broth of human embryonic lung diploid fibroblast, IMR-90 cells was one of the human hepatocyte growth factors (hHGFs). In the present report, we demonstrate its biological functions. F-TCF showed moderate cytotoxicity on human tumor cell lines KB, BG-1, MCF-7 and Hs913… CONTINUE READING