A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis

  title={A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis},
  author={Yan Li and D. A Lacerda and Matthew L Warman and David R Beier and Hidefumi Yoshioka and Y Ninomiya and Julia Thom Oxford and Nicholas P. Morris and Konstantinos Andrikopoulos and Francesco Ramirez and Bryan B. Wardell and G. D Lifferth and Cory Teuscher and Scott R. Woodward and Benjamin A. Taylor and Robert E. Seegmiller and Bjorn Reino Olsen},
Mice that are homozygous for the autosomal recessive chondrodysplasia (cho) mutation die at birth with abnormalities in cartilage of limbs, ribs, mandible, and trachea. Limb bones of newborn cho/cho mice are wider at the metaphyses than normal bones and only about half the normal length. By linkage analysis, the cho gene and the gene encoding the alpha 1 (XI) chain of cartilage collagen XI were mapped to the same region of chromosome 3. Deletion of a cytidine residue about 570 nt downstream of… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 45 references

A new chon

R. E. Seegmiller, F. C. Fraser, H. Sheldon
View 4 Excerpts
Highly Influenced

Assembly of cartilage collagen fibrils is disrupted by overexpression of normal type II collagen in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America • 1993
View 1 Excerpt

Mouse chromosome 3

M H.
Mammalian Genome • 1993

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