A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry.

@article{Steinman1996AFA,
  title={A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry.},
  author={Lawrence Steinman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 6},
  pages={2253-6}
}
  • Lawrence Steinman
  • Published 1996 in
    Proceedings of the National Academy of Sciences…
Inflammatory infiltrates in tissue-specific autoimmune disease comprise a collection of T cells with specificity for an antigen in the target organ. These specific cells recruit a population of nonspecific T cells and macrophages. The rare tissue-specific T cells in the infiltrate have the capacity to regulate both the influx and the efflux of cells from the tissue. Administration of an altered peptide ligand for the specific T cell which triggers autoimmunity can lead to the regression of the… CONTINUE READING

From This Paper

Topics from this paper.
71 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 71 extracted citations

Similar Papers

Loading similar papers…