A femtosecond laser pacemaker for heart muscle cells.

  title={A femtosecond laser pacemaker for heart muscle cells.},
  author={Nicholas Isaac Smith and Yasuaki Kumamoto and Shintaroh Iwanaga and Jyuko Ando and Keio Fujita and Satoshi Kawata},
  journal={Optics express},
  volume={16 12},
The intracellular effects of focused near-infrared femtosecond laser irradiation are shown to cause contraction in cultured neonatal rat cardiomyocytes. By periodic exposure to femtosecond laser pulse-trains, periodic contraction cycles in cardiomyocytes could be triggered, depleted, and synchronized with the laser periodicity. This was observed in isolated cells, and in small groups of cardiomyocytes with the laser acting as pacemaker for the entire group. A window for this effect was found to… CONTINUE READING

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