A feedback regulatory loop between HIF-1α and miR-21 in response to hypoxia in cardiomyocytes.

  title={A feedback regulatory loop between HIF-1α and miR-21 in response to hypoxia in cardiomyocytes.},
  author={Y Liu and Honggang Nie and Kuikui Zhang and D Ma and Guang Yang and Zhilei Zheng and Kai Liu and Bo Yu and Changlin Zhai and Shuang Yang},
  journal={FEBS letters},
  volume={588 17},
Accumulating evidence suggests that hypoxia-inducible factor 1α (HIF-1α) regulates numerous miRNAs and is crucial for cellular response to hypoxia. However, the relationship between HIF-1α and miR-21 in hypoxic cardiomyocytes is little known. We found that hypoxia induced HIF-1α and miR-21 expression. HIF-1α knockdown increased cell apoptosis and reduced miR-21 expression. Furthermore, we found that HIF-1α transcriptionally enhanced miR-21 promoter activity by binding to its promoter, which… CONTINUE READING
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