A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness

@inproceedings{Lee2016AFL,
  title={A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness},
  author={Sung-hun Lee and Tsai-Yu Chen and Shilpa Dhar and Bingnan Gu and Kaifu Chen and Young Zoon Kim and Wei Li and Min Gyu Lee},
  booktitle={Nucleic acids research},
  year={2016}
}
  • Sung-hun Lee, Tsai-Yu Chen, +5 authors Min Gyu Lee
  • Published in Nucleic acids research 2016
  • Biology, Medicine
  • Self-renewal and pluripotency are two fundamental characteristics of embryonic stem cells (ESCs) and are controlled by diverse regulatory factors, including pluripotent factors, epigenetic regulators and microRNAs (miRNAs). Although histone methyltransferases are key epigenetic regulators, whether and how a histone methyltransferase forms a network with miRNAs and the core pluripotent factor system to regulate ESC stemness is little known. Here, we show that the protein arginine… CONTINUE READING

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