A feed-forward circuit controlling inducible NF-κB target gene activation by promoter histone demethylation.

@article{Essen2010AFC,
  title={A feed-forward circuit controlling inducible NF-κB target gene activation by promoter histone demethylation.},
  author={Dominic van Essen and Yina Zhu and Simona Saccani},
  journal={Molecular cell},
  year={2010},
  volume={39 5},
  pages={750-60}
}
Activation of transcription from a silenced state is crucial to achieve specific gene expression in many biological contexts. Methylation of lysine 9 on histone H3 (H3K9) is widely associated with transcriptional silencing, and its disappearance is linked to the activation of several inflammatory genes by NF-κB. Here we describe that this event is controlled by a feed-forward circuit catalyzed by the activity of the histone demethylase Aof1 (also known as Lsd2/Kdm1b). We find that Aof1 is… CONTINUE READING

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