A feasibility study to evaluate a novel drug delivery technique through nasal/sinus mucosa using a biodegradable polymer in a guinea pig model.

@article{Jonnalagadda2011AFS,
  title={A feasibility study to evaluate a novel drug delivery technique through nasal/sinus mucosa using a biodegradable polymer in a guinea pig model.},
  author={Sashikanth Jonnalagadda and Vivian M Yu and Peter J. Catalano},
  journal={Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery},
  year={2011},
  volume={144 6},
  pages={978-81}
}
OBJECTIVE Targeted topical pharmaceuticals have fewer side effects than systemic therapy and present an interesting option to treat chronic sinus disease. A simple, dependable, resorbable drug delivery mechanism has been elusive. The goal of this study is to examine the feasibility of a novel bioresorbable synthetic polymer for drug delivery in nose and sinuses. STUDY DESIGN Feasibility study. SETTING Animal study. SUBJECTS AND METHODS Polyurethane sponges soaked in either triamcinolone… CONTINUE READING