A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

@article{Knowles2004AFA,
  title={A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.},
  author={Lynn M. Knowles and Fumiko T Axelrod and Cecille D. Browne and Jeffrey W. Smith},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 29},
  pages={30540-5}
}
In eukaryotes, fatty acid synthase (FAS) is the enzyme responsible for synthesis of palmitate, the precursor of long-chain nonessential fatty acids. FAS is up-regulated in a wide range of cancers and has been suggested as a relevant drug target. Here, two independent approaches are taken toward knocking down FAS and then probing its connection to tumor cell proliferation. In one approach, Orlistat, a drug approved for treating obesity, is used as a potent inhibitor of the thioesterase function… CONTINUE READING